Prevalencia de HLA-B27 y características clínicas de una cohorte de pacientes con espondiloartropatías en el Hospital Luis Vernaza del 2015 - 2016.

Abstract

Introduction: HLA-B27 is a laboratory test used in the diagnosis of spondyloarthritis (SpA). This paper's objective is to determine its prevalence and the clinical characteristics of patients with SpA who attended the external consult of rheumatology in the Luis Vernaza Hospital (HLV) from 2015 to 2016. Methodology: A list of patients whom HLA-B27 was done from 2015 to 2016 was requested from the HLV department of molecular biology, and once a sample was extracted (189 patients) we investigated a group of clinical and laboratory variables relevant to the study of SpA in the Servinte system. The database was analyzed in SPSS using statistical tools as frequencies, chi squared, odds ratio and confidence intervals. Results: HLA-B27 prevalence was (12.7%). Psoriatic arthritis frequency was (47.6%). Mixed clinical forms frequency was (63%). 138 patients (73.02%) had low back pain and 112 (59.26%) had enthesitis. 84 patients (44.44%) had psoriasis. We found a significant relation between positive HLA-B27 and low back pain (p: 0.0275) and sacroiliitis (p: 0.0053), and negative HLA-B27 and arthritis (p: 0.0111). Conclusions: HLA-B27 prevalence was low. Psoriatic arthritis was the most frequent SpA, mixed form was the most frequent, low back pain and enthesitis were the most prevalent rheumatic symptoms and psoriasis the most prevalent extraarticular symptom. There was a significant relation between positive HLA-B27 and low back pain and sacroiliitis, and negative HLA-B27 and arthritis.