Valor predictivo del perfil de coagulación en la morbilidad y mortalidad por pancreatitis aguda en el Hospital General del Norte de Guayaquil Los Ceibos durante el periodo enero 2017 a enero 2019.

Abstract

Background: Microvascular changes have been shown to be significant events in the progression of acute pancreatitis and that bleeding disorders are related to their severity. However, significant studies on the clinical value of coagulation system parameters in predicting mortality and morbidity from organ failure are still scarce. It is essential to carry out a study that provides data on the usefulness of various parameters of the coagulation profile on morbidity and mortality in cases of acute pancreatitis. Objectives: The main objective of the study was to determine the positive predictive value of alterations in the coagulation profile on morbidity and mortality from acute pancreatitis. Materials and methods: A cross-sectional, observational and descriptive study of patients with a diagnosis of acute pancreatitis taken from the Hospital General Norte de Guayaquil Ceibos during the period 2017-2019 was performed. Results: 133 subjects were included in the study. Of the subjects studied, 80 (60.15%) were female patients, the average age was 50.9 years (+ -1.60), the BMI was 26.2 Kg / m2 (+ -0.42) and the average hospital stay was 12.68 days (+ - 0.78). The TP (p <0.000) was statistically significant for morbidity and mortality. The other variables, both platelets and TPPa were significant in mortality, but not in morbidity (p <0.509 and p <0.079) respectively. Conclusion: Prolonged prothrombin time at admission or altered INR may be a useful marker in predicting the development of organ failure and mortality from acute pancreatitis.