Asociación entre valores de hemoglobina glicosilada con desarrollo de hemorragia intracerebral espontánea en pacientes de 40-70 años del Hospital Naval de Guayaquil desde 2015 al 2019.

Abstract

Background: Intracerebral hemorrhage (ICH) is considered the third disabling cause worldwide. In South America, ICH causes between 60 to 70 cases per 100,000 inhabitants per year. On 2016, Acute Stroke caused 3,878 deaths and 1,406 of this were by ICH in Ecuador. High levels of Glycosylated Hemoglobin (HbA1c) have been associated with a higher incidence of ICH. Objective: Evaluate the relationship between Glycosylated Hemoglobin levels and development of Spontaneous Intracerebral Hemorrhage (SICH). Methods: A retrospective, analytical, relational, observational study of patients with SICH and their HbA1c’s values versus a control group without SICH and their HbA1c’s values admitted in “Hospital Naval de Guayaquil” between 2015-2019. Results: We obtained a total of 45 patients with SICH and 45 patients without SICH. We found an association between elevated HbA1c’s values and incidence of SICH with (OR = 2.75, P <0.001). In addition, hypertension (OR = 2.69) and female sex (OR = 1.854) were associated with SICH. The mortality was higher in those without diagnosis of diabetes with 46% versus those with diagnosis of diabetes with 15% (P = 0.048). Conclusion: There was association between elevated HbA1c’s values and occurrence of SICH, in patients with and without diagnosis of diabetes before the hemorrhage.