Asociación del Helicobacter pylori con el cáncer gástrico, en pacientes mayores de 50 años en el Hospital General del Norte de Guayaquil Los Ceibos, en la ciudad de Guayaquil, en el periodo 2018 – 2020.

Abstract

Introduction Gastric cancer is characterized by a high mortality rate and is the second leading cause of cancer death after prostate cancer. Helicobacter pylori is the most important etiological factor of gastric cancer. It is estimated that 78% of gastric cancer cases are attributed to H. pylori infection. During H. pylori-induced chronic inflammation and subsequent carcinogenesis, a variety of factors including bacterial factor, host factors and environmental factors interact to form a complex network to respond to inflammation and facilitate damage repair. Altered cell proliferation, apoptosis and some epigenetic modifications of tumor suppressor genes may occur. These changes may eventually lead to oncogenesis and subsequent gastric cancer. Objective To determine the association of Helicobacter Pylori and gastric cancer in patients older than 50 years at the Hospital General del Norte de Guayaquil Ceibos, in the city of Guayaquil, in the period 2018-2020. Materials and methods. This is an observational, cross-sectional, analytical and retrospective type of research, whose source comes from the database of patients over 50 years of age who have been diagnosed with the ICD 10 code of the pathology in the Hospital General del Norte de Guayaquil Ceibos in the period 2018-2020. Conclusions A direct relationship between the presence of Helicobacter pylori and gastric cancer can be determined.