Asociación entre niveles séricos de creatina-fosfocinasa (CPK) e injuria renal aguda en pacientes politraumatizados con criterios de rabdomiólisis del HGNG Los Ceibos durante el periodo 2021-2022.

Abstract

Introduction: Acute kidney failure induced by rhabdomyolysis occurs after a damage has been done do the muscle fiber, releasing to the circulatory system myoglobin and other compounds found on the inner compartments of the muscle cell. Objective: This study aimed to analyze the association between serum CPK levels and AKI in polytraumatized patients with rhabdomyolysis treated at the HGNG Los Ceibos between 2020 and 2023. Methodology: A retrospective observational study was carried out, analyzing the clinical and laboratory data of 333 patients with diagnosis of rhabdomyolysis and polytrauma treated at the HGNG Los Ceibos. Data were collected on demographic characteristics, serum CPK levels, renal function parameters, and the presence of AKI according to KDIGO criteria. A statistical analysis was performed to determine the association between CPK levels and creatinine levels, using assessment tests and logistic regression analysis. Results: A significant association was found between serum creatine phosphokinase (CPK) levels and acute kidney injury (AKI) in polytraumatized patients with rhabdomyolysis criteria.