Evaluación de los niveles sistémicos mediante medición de Pcr-us en pacientes con periodontitis.

Abstract

Introduction: Periodontitis is a chronic inflammatory disease associated not only with the deterioration of tooth-supporting tissues but also with systemic inflammatory processes. High-sensitivity C-reactive protein has been proposed as a biomarker to evaluate this relationship. Objective: To evaluate the relationship between periodontal severity and high-sensitivity C-reactive protein levels in patients with periodontitis treated at the Dental Clinic of the Catholic University of Santiago de Guayaquil during the 2025–2026 period. Methodology: Quantitative, observational, descriptive, cross-sectional study. The sample consisted of 29 patients diagnosed with periodontitis. Clinical periodontal evaluation and blood sample collection were performed for the serum determination of hs-CRP. Due to the non-normal distribution of the data, non-parametric statistical tests were applied, including Cuzick’s test, Kruskal-Wallis test, Mann-Whitney U test, and Spearman correlation, with a significance level of p<0.05. Results: Descriptive analysis showed an upward trend in the median hs-CRP as periodontal stage increased, with lower values in stage II and higher values in stages III and IV. However, Cuzick’s test (z = 0.704; p = 0.4811), Kruskal-Wallis (χ² = 2.628; p = 0.4539), and Spearman correlation (rho = 0.1367; p = 0.4795) did not show statistically significant associations. Significant differences were observed according to sex. Conclusions: An upward descriptive trend in hs-CRP levels was observed as periodontal severity increased; however, this relationship did not reach statistical significance.