Análisis comparativo de la estabilidad de Articaína 4% y Mepivacaína 2% a diferentes temperaturas. UCSG, semestre B 2017.

Abstract

Introduction: One of the main goals in Dentistry is pain control, for this reason many theories have been proposed in order to decrease discomfort and calm the anxiety of the patient during the treatment. One of the theories is to heat the anesthetic solution at the level of body temperature to decrease pain at the time of puncture; this theory has only been asessed in clinical studies on lidocaine. Several studies have not been carried out on the stability of Articaine and mepivacaine at different temperatures. Objective: To compare the stability of the components in two different types of anesthetics at diverse temperatures. Materials and Methods: An experimental cross-sectional study was carried out in which a sample size of 90 cartridges divided into 2 groups of 45 anesthetics was determined for each assigned group. In order to perform the study of the components, the thin-layer chromatography technique was used, in addition pH was analyzed using a potentiometer at room temperature, after which the anesthetic was taken at different temperatures to later return to the ambient temperature to analyze stability. To measure the acid dissociation constant, the Henderson Haselbach equation was used. Results: When increasing the temperature in both anesthetics, pH, pka and epinephrine were affected, which did not return to their initial pH. Articaine showed less stability, Likewise, the tested anesthetic did not differ significantly. Conclusion: Stability was affected in both anesthetics, being affected in less quantity in mepivacaine 2% compared to Articaine 4%.