Prevalencia de efectos adversos relacionados al régimen de acondicionamiento en pacientes que recibieron trasplante de precursores hematopoyéticos.

Abstract

The conditioning regimen used in the transplantation of haematopoietic precursors has the function of eliminating the disease and allowing transplanted cells to graft, classified according to their intensity, in myeloablative, non-myeloablative and reduced intensity conditioning, which use highly toxic drugs , which present adverse effects such as nausea, vomiting, diarrheal syndrome, hemorrhagic cystitis, and veno-occlusive disease, whose objective is aimed at determining the prevalence of adverse effects caused by the conditioning regimen in patients who received TPH, where methodologically A retrospective, analytical, cross-sectional study (observational, descriptive, retrospective, and observational type) was conducted at the Juan Tanca Marengo Institute in Guayaquil between 2008- 2017 and results in the prevalence of adverse effects were 78, 83%, of these the scheme that more pr These effects were estimated to be busulfanCyclophosphamide with 51.67% (p = 0.001). Of the total of 30 adverse effects, gastric toxicity with 45.63% was the most frequent, 89.91% in the early post-transplant phase and 45.65% of the cases were resolved in a period of 2 weeks, and only 5.36% died, so it was possible to conclude that the adverse effect that occurred was gastric toxicity. The prevalence of adverse effects is high. in comparison with other studies, and more than half of the adverse effects were related to the BuCy2 scheme, so it is suggested to use an alternative scheme, despite this, mortality is almost nil.