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Please use this identifier to cite or link to this item: http://repositorio.ucsg.edu.ec/handle/3317/13569
Title: Prevalencia de mutaciones genéticas en adenocarcinoma de pulmón en pacientes entre 18 y 95 años del Hospital Luis Vernaza durante el periodo 2016 - 2018.
Authors: Cabrera Polit, Carlos Francisco
Velasco Gaibor, Anthony Paúl
metadata.dc.contributor.advisor: Benites Estupiñan, Elizabeth María
Keywords: ONCOLOGÍA;CÁNCER DE PULMÓN;ADENOCARCINOMA DE PULMÓN;TABAQUISMO;MUTACIONES GENÉTICAS;HÁBITOS CONDUCTUALES;FACTORES DE RIESGO
Issue Date: 10-Sep-2019
Publisher: Universidad Católica de Santiago de Guayaquil
Abstract: INTRODUCTION: Lung adenocarcinoma is a type of non-small cell cancer, whose incidence is increasing in both sexes. Currently, certain genetic mutations can be identified in order to start with a targeted therapy. It has been shown that its incidence is directly associated with environmental factors than hereditary factors. METHODOLOGY: Observational, descriptive, cross-sectional, retrospective study. In which a database of 20 records of medical records of patients treated during January 2016 to December 2018 at the Luis Vernaza Hospital, confirmed with lung adenocarcinoma, was generated. Data collection was carried out in an Excel 2016 workbook and later tables and statistical analysis were generated. RESULTS: Of the 20 patients with lung adenocarcinoma, 20% had genetic mutations, 15% had hypertension and 10% had type II diabetes. Age is related to survival because there is a high risk (25.0) of people who are over 66 (average age) are less likely to survive in patients with lung adenocarcinoma. 60% of patients are chronic or passive smokers. In the Pearson Correlation test, the types of mutations are not related to Lung Adenocarcinoma, therefore the null hypothesis was accepted since r = .248> p = 0.05, which shows that the majority of these patients do not they have a genetic predisposition with Lung Cancer, but if these mutations are related to behavioral and environmental habits. CONCLUSIONS: Adenocarcinoma of the lung type is a disease that has the greatest impact on environmental factors, and that its survival rate decreases as soon as it is diagnosed at more advanced ages. It can also be concluded that lung adenocarcinoma has a higher incidence in males, in people over 66 years of age and the survival rate decreases to 25%. 60% of cases are directly related in chronic or passive smoking patients. Preventive education is suggested and to investigate mutations in individuals predisposed to degenerative and obstructive diseases for personalized genetic treatments whose sensitivity is greater than conventional treatment.
Description: INTRODUCION: El adenocarcinoma de pulmón, es un tipo de cáncer no microcítico, que su incidencia va en aumento en ambos sexos. Actualmente se pueden identificar ciertas mutaciones genéticas del mismo, para así poder iniciar con una terapia dirigida. Se ha demostrado que su incidencia asociada directamente a factores ambientales que a factores hereditarios. METODOLOGIA: Estudio Observacional, descriptivo, transversal, retrospectivo. En el cual se generó́ una base de datos de 20 expedientes de historias clínicas de pacientes atendidas durante enero del 2016 a diciembre 2018 en el Hospital Luis Vernaza, confirmados con adenocarcinoma de pulmón. La recolección de datos se realizó́ en un libro de Excel 2016 y posteriormente se generaron tablas y análisis estadístico. RESULTADOS: De los 20 pacientes con Adenocarcinoma de Pulmón el 20% presentaron mutaciones genéticas, el 15% Hipertensión y el 10% Diabetes tipo II. La edad está en relación con la supervivencia porque hay un alto riesgo (25.0) de personas que tienen más de 66 (edad promedio) tienen menos probabilidad de supervivencia en los pacientes con adenocarcinoma de pulmón. El 60% de los pacientes son fumadores crónicos o pasivos. En la prueba de Correlación de Pearson, los tipos de mutaciones no están relacionados con el Adenocarcinoma de Pulmón, por lo tanto, se aceptó la Hipótesis nula ya que r= .248 > p= 0.05, lo que demuestra que la mayoría de estos pacientes no tienen predisposición genética con el Cáncer de Pulmón, pero si estas mutaciones están relacionadas con hábitos conductuales y ambientales.
URI: http://repositorio.ucsg.edu.ec/handle/3317/13569
Appears in Collections:Trabajos de Titulación - Carrera de Medicina

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