Comparación entre el Score SOFA (Sequential Organ Failure Assessment score) vs los biomarcadores inflamatorios y microcirculación como predictores temprano de mortalidad en pacientes con sepsis ingresados en la Unidad de Cuidados Intensivos del Hospital de Especialidades Teodoro Maldonado Carbo de la ciudad de Guayaquil desde enero 2016 hasta enero 2019.

Abstract

Sepsis is the body's deregulated response to a life-threatening infection that causes organ dysfunction. Currently, it is one of the main reasons for admission to the Intensive Care Unit; in the worldwide, it is the main cause of mortality in that it requires immediate identification, care and specialized treatment. Objective: To determine the best early predictor of mortality, between the SOFA score vs. the inflammatory and microcirculatory biomarkers, in patients with sepsis admitted to the Intensive Care Unit of the Teodoro Maldonado Carbo Specialty Hospital in Guayaquil's city, in the period from January 2016 to January 2019. Method: The study is observational, retrospective, and analytical, with a universe of 1308 patients, of which 103 patients met inclusion criteria. Results: The male sex presents more risk to develop sepsis with 57.28%. The range of age between 56 to 80 years old, represents 47%. The most frequent infectious focus is the gastrointestinal with 35,7%. The most associated with sepsis comorbidity is hypertension with 24.27%. The C-reactive protein shows high probability of death with 51,4%. Regarding the sensitivity of the tests, the C-reactive protein has 20.90%, procalcitonin 61.79%, lactate 17.91%, and SOFA score 67.16%. Regarding the specificity, lactate had 94.44%. Conclusion: The earliest predictor of sepsis severity is the score SOFA with 67.16% of test sensitivity, and 66.67% of test specificity.