Efectos adversos de la terapia con modificadores de la respuesta biológica en pacientes con Artritis Psoriásica del hospital Teodoro Maldonado Carbo y su relación con factores asociados.

Abstract

Introduction: Inhibitors of tumor necrosis factor alpha are used in the treatment of psoriatic arthritis and sometimes they present adverse effects that require the replacement of them. Methodology: Relational, cross-sectional and retrospective study. Objective: To relate the comorbidities of patients with psoriatic arthritis at Hospital Teodoro Maldonado Carbo with a higher risk of presenting adverse reactions due to the use of biological therapy. Results: 570 patients with biological therapy from the outpatient clinic of the Teodoro Maldonado Carbo Hospital were analyzed, 120 had a diagnosis of psoriatic arthritis, of whom 97 met the inclusion criteria. Of these, 73 (75.3%) used biological therapy throughout the study period. The pacients that presented adverse effects were 11 (15.1%). The most frequent were dyspepsia (3, 27.3%) and dizziness-vomiting (3, 27.3%). The most common comorbidities were hypertension (26 cases), diabetes mellitus (18 cases) and ulcer-peptic disease (16 cases). Spearman's correlation between comorbidities with adverse effects attributable to the biological therapy was -0.129. Conclusion: It was determined that patients with psoriatic arthritis who present comorbidities have no greater risk of having adverse effects when using anti-TNF-α biological therapy than those who do not report comorbidities.