Efectos adversos asociados al tratamiento farmacológico en pacientes con trastorno depresivo mayor de entre 20 a 40 años de edad en el Hospital de Especialidades “Teodoro Maldonado Carbo” durante el año 2014 hasta el año 2019.

Abstract

Depression encompasses emotional disorders characterized by a sad state of mind, along with a group of neurovegetative, behavioral, cognitive and physical manifestations. It is highly frequent and disabling, it is accompanied by considerable morbidity, mortality, costs and an increased risk of suicide. Objective: To know the clinical profile, the most commonly used drugs and adverse effects reported by patients diagnosed with major depressive disorder. Materials and methods: Descriptive, observational, retrospective study in 512 patients diagnosed with depression disorder between 20 and 40 years of age at the Teodoro Maldonado Carbo Hospital. Results: Of the total sample, 22.1% are men and 77.9% are women; the average age was 30 years. 35% were without depression according to the Hamilton scale, 45.9% with mild depression, 13.3% with moderate depression and only 5.9% were classified as severe depression. Of the total patients, 60.5% received monotherapy, 34.2% received two to three drugs, and 27 (5.3%) used more than three drugs. The most prescribed family were the SSRIs, representing 62.3%. Regarding adverse effects, the most common was weight change (23%), followed by neurological symptoms (17%), gastrointestinal (12.6%), other (11.7%) sexual dysfunction (11.2%). Conclusions: Major depressive disorder is more frequent in the female gender at an average age of 30 years, most of them are classified as mild depression under the monotherapy modality and the most reported adverse effects are: weight change, neurological and gastrointestinal symptoms, and sexual dysfunction.