Amoniaco sérico como factor predictivo de mortalidad en pacientes con encefalopatía hepática secundaria a cirrosis hepática en el Hospital Teodoro Maldonado Carbo en el periodo de enero del 2018 a enero del 2019.

Abstract

Introduction: Cirrhosis is considered the final stage of liver parenchyma damage, secondary to multiple etiologies which cause changes in terms of morphology, anatomy, and histopathology. Hepatic encephalopathy is one of the most frequent complications in cirrhotic patients and is associated with high mortality. This study aims to associate hyperammonemia in patients with hepatic encephalopathy secondary to cirrhosis. Methodology: An observational, retrospective and crosssectional study was conducted. The size of the sample consists of 232 patients diagnosed with fibrosis and cirrhosis of the liver and hepatic encephalopathy. Data was obtained from medical records in the AS400 system, at the Teodoro Maldonado Carbo Hospital during the period from January 2018 to January 2019 tabulated with Microsoft Excel and processed with the SPSS software. Results: A sample of 232 patients was obtained whit a mean amount of ammonium was 124, 9 mcg/dl, the variable mortality and ammonium values were related, where it was obtained that 61 did not die within 30 days of hospital stay with high ammonium figures (47.3 %), while 68 patients died within 30 days of hospitalization with hyperammonemia (52.7%). Conclusions: In this study it was concluded that there is an association between hyperammonemia and mortality because a larger number of patients with an abnormally exceeded amount of ammonium deceased, in addition it was determined that a considerable number of patients with decompensated cirrhosis had hyperammonemia. Finally, patients with hepatic encephalopathy were associated with certain complications such as ascites, esophageal varices and hemorrhage of varicose vein origin.