Prevalencia de enterobacterales productoras de carbapenemasas en pacientes diagnosticados con VIH en diferentes hospitales de Guayaquil – Ecuador.

Abstract

Introduction: Nowadays, carbapenemase-producing Enterobacteral infections (CPE) imply great clinical difficulty worldwide. They are involved in the etiology of bacterial infections in patients with HIV / AIDS, they occur in individuals with a number of CD4 + T lymphocytes less than 100 cells / mm3. Objectives:To analyze the prevalence of Carbapenemase-producing Enterobacteral infections in patients diagnosed with HIV in six hospitals in Guayaquil – Ecuador between 2019-2020. Materials and methods: A descriptive-retrospective study was carried out. The universe was the patients with CPE isolation and HIV diagnosis. 191 hospitalized patients were studied, of which 10 had a diagnosis of HIV. Patients who met the inclusion criteria were selected. Results: The prevalence of CPE in HIV patients was 5.23%, predominantly male: 80% (n = 8); with an average age of 33 ± 11.12 years. Neurological disease was associated in 50% (n = 5), while the main comorbidity presented in 80% (n = 8) had immunosuppression. The most frequent isolated microorganisms were Klebsiella pneumoniae 50% (n = 5), Enterobacter oxytoca 20% (n = 2) and Enterobacter cloacae 20% (n = 2). Regarding empirical antimicrobial treatment Conclusions: CPE infection is an important cause of morbidity and mortality worldwide, however, the least susceptible to contracting infection are HIV patients who are on established antiretroviral treatment. Therefore, it is important to establish preventive measures according to our environment and thus be able to make a worldwide comparison.