Factores de riesgos asociados a la mortalidad de bacteriemia por enterobacterales resistentes a carbapenémicos en el Hospital Teodoro Maldonado Carbo durante el período 2017-2020.

Abstract

Introduction: carbapenem-resistant Enterobacteriaceae (CRE) infections are a problem that have increased worldwide in recent years and represent an important cause of mortality in hospital patients. Although the factors that influence the development of this type of infection in patients are known, little is known about the factors that increase mortality from this specific type of infection. Methodology: A retrospective cross-sectional study was carried out with a population of 102 hospitalized patients with bacteremia due to carbapenem-resistant Enterobacteriaceae, of whom demographic factors, comorbidities, invasive procedures, use of adequate antibiotic therapy, as well as SOFA and APACHE II scores were collected, and their evaluation was studied. relation to patient mortality Results: The factors with a significant relationship to the mortality of these patients were septic shock (p=0.0008), oncohematological diseases (p= 0.035) and major surgery (p=0.048). The use of adequate empirical antibiotic therapy given in 11 of the 102 patients presented a mortality of 8.82%, however, no relationship was established with the mortality of the patients (p=0.772). The SOFA and APACHE II scales were shown to be related to the mortality of patients with these infections, increasing the risk 28.63 times if the SOFA is greater than 7 (p=0.0205) and 7.76 if the APACHE II is greater than 20 (p=0.0020). Conclusion: patients who are complicated by septic shock, suffer from oncohaematological diseases or have had major surgery, have a high risk of mortality from bacteremia due to CRE. Adequate empirical antibiotic therapy is not related to mortality in patients with bacteremia due to CRE. The SOFA and APACHE II scales with high scores are related to a higher risk of mortality in patients with bacteremia due to CRE.