Patrones de resistencia antimicrobiana en Enterobacterales resistentes A Carbapenémicos en diferentes Hospitales de Guayaquil – Ecuador durante el periodo de enero del 2019 - julio 2020.

Abstract

Introduction: Antimicrobial resistance is a major problem worldwide, among them are Enterobacteriaceae, and as time goes by, antibiotics lose sensitivity and effect on these pathogens. Objective: To determine the antimicrobial susceptibility of carbapenem-resistant Enterobacteriaceae in six hospitals in Guayaquil, during the study period January 2019- July 2020. Materials and Methods: A retrospective study was conducted in 3 public and 3 private hospitals in Guayaquil. Patients with positive cultures for carbapenem-resistant Gram-negative bacteria isolated during January 2019 to July 2020 at the study sites were included. Antibiograms were reviewed and corresponding information was collected to which a database was elaborated in an Excel file and the data was processed in IMB SPSS. Frequency values were finalized for the qualitative variables of the study. From there, the significance of the variables with respect to sensitivity and resistance with respect to MIC of each antimicrobial studied was calculated. Results: In this analysis, it was determined that the high rate of resistance reflected in the samples taken was due to gram-negative germs, especially to carbapenemic antimicrobials. Conclusions: In conclusion, carbapenemics showed high resistance in most of the samples. Among the antibiotics studied, colistin and tigecycline showed better sensitivity rates.