Índice leucoglucémico como marcador predictor del déficit neurológico en la enfermedad cerebrovascular isquémica aguda del hospital de especialidades Guayaquil Dr. Abel Gilbert Pontón, enero 2020 - marzo 2023.

Abstract

Introduction: In recent years, many authors propose the potential predictive effect of the leukoglycemic index as an early marker of neurological deficit in patients with acute ischemic stroke. Through the pathophysiological mechanisms that promote leukocytosis and hyperglycemia, it ends up favoring a greater extension of the infarction. Objective: To determine the usefulness of the leukoglycemic index as a predictor marker of neurological deficit in acute ischemic cerebrovascular disease. Methodology: Observational, retrospective, cross-sectional, relational and predictive study. We included 150 patients with acute ischemic CVD from the Hospital Guayaquil Dr. Albert Gilbert Pontón, January 2020 – March 2023. The information obtained was stored in an Excel database, SPSS software was used for descriptive and inferential statistical analysis and a diagnostic test calculator was used for the fagan nomogram. Results: A cut-off point of 1546.08 was determined with a sensitivity of 78% and specificity of 97.2%, with AUC .89 (CI: .826 - .962) significant (p < .001). Bivariate analysis between ILG and severity showed statistically significant association (X2 = 94.42; p <.001). The correlation between ILG and NIHSS score was moderate and positive direction, rho value (148) = .588, p<.001. A PPV= .914; NPV= .921; LR+ of 28 CI95% (9.18 - 88); LR- of .23 CI95% (.13 - .40) was determined. Conclusions: High leukoglycemic index would increase the probability by 63.7% of belonging to the severe group of neurological deficit following an ischemic cerebrovascular event.