Prevalencia del virus de Epstein-Barr en los pacientes con linfoma difuso de células B grandes, en el Hospital SOLCA Guayaquil 2016 -2019.

Abstract

Background: Diffuse large B-cell lymphoma (DLBCL) is the most common histologic subtype of non-Hodgkin lymphoma, the incidence of which increases with age. The Epstein-Barr virus (EBV) is distributed worldwide. The association between DLBCL and EBV is close to 10% in immunocompetent patients; this type of lymphoma has a high prevalence in Latin American countries. Objective: To determine the prevalence of the Epstein-Barr virus in patients with diffuse large B-cell lymphoma, treated at the SOLCA Guayaquil Hospital, 2016 - 2019. Methodology: Observational, descriptive, retrospective and cross-sectional study. The clinical and pathology records of patients diagnosed with DLBCL and in situ hybridization performed for the detection of EBV (EBER) are reviewed. Result: Between 2016 and 2019, the clinical history of 104 patients diagnosed with DLBCL was reviewed. 10% were EBV positive and 2% LMP1 positive, of which the majority were not germinal center (9%), predominating in extranodal organs (6%), there was a higher prevalence in women (8%), and death in the 3% of cases. Conclusion: The frequency of the Epstein-Barr virus in patients diagnosed with diffuse large B-cell lymphoma at the SOLCA Guayaquil hospital is 13.9% (by EBER), and 2.8% (by LMP1), being EBER the gold standard in tissue.