Caracterización de pacientes con talla baja por Deficiencia de Hormona de Crecimiento en tratamiento de reemplazo hormonal en el Hospital del Norte de Guayaquil IESS Los Ceibos durante el periodo 2018-2022.

Abstract

Introduction: Short stature constitutes the first reason for consultation in pediatric endocrinology. Short stature is considered to be that with a standard deviation (SD) of less than -2 units with respect to the mean of the reference population for the same age and sex. Objective: To determine the characterization of patients with short stature due to growth hormone deficiency undergoing hormone replacement treatment at the Hospital del Norte de Guayaquil IESS Los Ceibos during the period 2018-2022. Methodology: 114 patients with short stature due to GH deficiency who attended the Hospital General del Norte IESS Los Ceibos were selected, meeting the inclusion and exclusion criteria to carry out this observational, retrospective, cross-sectional and descriptive study. Results: The average age at which patients came for endocrinology consultation was 10 years, the predominance of male sex was identified (73.6%), the predominant origin was the urban area (Guayaquil) (65%). It was also identified that the average initial height with which patients come to endocrinology consultation is 1,24 m. Regarding personal pathological history, the frequency of non-endocrinological pathologies prevailed with a total of 102 patients, 6 patients had hypothyroidism, 2 patients reported having pituitary lesions and 4 patients reported having other endocrinopathies. And in relation to the diagnostic methods implemented, it was observed that the great majority of the study population underwent these procedures reflecting the following results: Insulin stimulation test (90.4%), Insulinlike Growth Factor Type 1 (IGF1) (95.6%), Magnetic Resonance Imaging (85.1%), Cartogram (94.7%). Conclusion: The analysis of our sample showed the following: predominance of male gender, average age of onset of endocrinological care around 10 years (indicating a late access in comparison with recommended guidelines), average height at first consultation of 1.24 meters, majority of patients of urban origin (especially from Guayaquil), little history of personal endocrinological pathologies, although cases of hypothyroidism and lesions in the pituitary gland were identified. Other endocrine conditions present did not have a significant impact on the analysis. Most of the population studied underwent the diagnostic methods included in the study.