Procalcitonina/proteína C reactiva (PCT/PCR) como indicador de pronóstico en pacientes con sepsis respiratoria de la Unidad de Cuidados Intensivos del Hospital de Especialidades Teodoro Maldonado Carbo en el año 2024.

Abstract

Introduction: Respiratory sepsis is an organ dysfunction caused by a dysregulated response to a respiratory tract infection, representing a significant cause of morbidity and mortality. Objective: To evaluate the prognostic value of procalcitonin/C-reactive protein (PCT/CRP) in patients with respiratory sepsis in the Intensive Care Unit of the Teodoro Maldonado Carbo Specialty Hospital in 2024. Methodology: This study has an observational, analytical, retrospective, and cross-sectional design. Results: Sixty-two patients with respiratory sepsis were included, predominantly male (54.8%) and with a median age of 68 years (IQR: 17–90). The most frequent comorbidities were hypertension (62.9%) and type 2 diabetes mellitus (32.3%). The severity score obtained a SOFA in low and intermediate risk (28.3% and 23.3%), APACHE II in moderate dysfunction (58.1%), and a median ICU stay of 29 days (IQR: 2–180); 61.3% required mechanical ventilation, 54.8% required vasopressors, and mortality reached 38.7%. The most frequent etiological agent was Acinetobacter calcoaceticus-baumannii complex (37.1%), and the predominant associated pathology was bacterial pneumonia (85.5%).The PCT/PCR index showed significantly higher values in the non- survivor group (median 0.09 vs. 0.03; p < 0.001). The cutoff point of 0.04 (Sn: 87.5%, Esp: 78.9%), and AUC of 0.818 (95% CI: 0.724–0.912), demonstrated substantial predictive ability. Conclusion: The PCT/CRP index is a reliable prognostic marker in patients with respiratory sepsis, reflecting clinical severity and correlating with mortality.