Efectos de la Glutamina intravenosa® en mucositis oral en pacientes con trasplante de médula ósea del Hospital Dr. Juan Tanca Marengo.

Abstract

Glutamine is a semi-essential amino acid useful under stress conditions. In this case, the main function of glutamine is to decrease the adverse effects of chemotherapy (CT) and radiotherapy (RT). The aim of the following study is to demonstrate the effects of glutamine supplementation on the recovery of oral mucositis in patients that underwent a bone marrow transplant. The retrospective study included 50 patients who developed oral mucositis when submitted to CT and / or RT in the 2009 to 2017 period. The sample was divided into 2 groups: GLN group (n=25) that were given the Dipeptiven ampoule (13g of glutamine in 20% solution) and NO GLN group (n=25). The variables considered were recovery time, immune system function, use of analgesics and development of infections. From the performed data analysis, it was determined that a significant relationship between the glutamine administration and the recovery time for oral mucositis (p=,04). Even if an association between the immunologic cells recount and the dipeptide administration did not exist, it was possible to observe a relevant increase in the amount of cells in the GLN group. The relationship between the use of analgesics and the development of infections was non-existent. To conclude, the supplementation of L-glutamine decreases the recovery time for oral mucositis on the studied group of patients.