Asociación de los Índices neutrófilo-linfocito (INL/NLR), plaquetas-linfocitos (IPL/PLR) y PIM III, con severidad en PIMS post COVID 19, en niños Hospitalizados en UCIP del Hospital Pediátrico Roberto Gilbert Elizalde, entre julio del 2020 y julio del 2021.

Abstract

In patients with severe post-COVID-19 Pediatric Multisystem Inflammatory Syndrome (PIMS) admitted to the PICU, it is important to predict the severity of the condition. The PIM III is highly sensitive and specific, and the neutrophillymphocyte (NLR) and platelet-lymphocyte (PLR) indices are simpler, also sensitive, and specific and are calculated on admission with the first blood count obtained. Objective: To determine the association of the neutrophillymphocyte (NLR), platelet-lymphocyte (PLR) indices with the PIM III measured as predictors of severity in PIMS post COVID 19, in children hospitalized in the PICU of the Roberto Gilbert Elizalde Pediatric Hospital, among July 2020 to July 2021. Method: Descriptive, retrospective, crosssectional study, it is descriptive with association of variables and data obtained in medical records. This study included 112 patients between 1 month and 17 years. Absolute frequencies and percentages were used for the analysis of the qualitative variables and for the quantitative variables, dispersion measures were used, ROC curve, sensitivity, specificity, PPV and NPV were calculated. Results: 51.8% of the admitted children were male, 33% were between 1 and 5 years old, the NLR index registered a mean of 5.33, the PLR 336.53 and the PIM III 44 directly related to the severity of the condition. The area under the ROC curve was 0.788 for PLR, 0.750 for PIM III, and 0.683 for NLR. Sensitivity and specificity were 75% and 51.9% for NLR, 83.3% and 42.3% for PLR, and 86.7% and 42.3% for PIM III. All indices presented a significant association with severity. Conclusion: The NLR and PLR indices are simple and useful tools to predict severity in post-COVID-19 PIMS patients admitted to the PICU.